Side-by-Side Comparison · 2026

Leuphasyl vs Rigin

Leuphasyl vs Rigin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Leuphasyl
Cosmetic Peptide

Leuphasyl (Acetyl Pentapeptide-18) is a synthetic cosmetic peptide designed to mimic enkephalin activity at opioid receptors in skin. Enkephalins are endogenous neuropeptides that modulate skin neurogenic inflammation and tension signaling in facial muscles....

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Rigin
Cosmetic Peptide

Rigin (Palmitoyl Tetrapeptide-7) is a cosmetic peptide with the sequence Pal-GQPR derived from the immunoglobulin G (IgG) Fc region. It is designed to suppress chronic skin inflammation by reducing interleukin-6 (IL-6) production in skin fibroblasts and keratinocytes....

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Key Parameters
Parameter Leuphasyl Rigin
Category Cosmetic Peptide Cosmetic Peptide
Research Cosmetic Use Cosmetic Use
Half-Life Hours (skin) Hours (skin)
Typical Dose 0.001-0.01% in formulation 0.001-0.01% in formulation
Frequency Twice daily Twice daily
Route Topical Topical
FDA Status Cosmetic ingredient (not drug) Cosmetic ingredient

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Frequently Asked Questions
What is the difference between Leuphasyl and Rigin?
Leuphasyl: Leuphasyl (Acetyl Pentapeptide-18) is a synthetic cosmetic peptide designed to mimic enkephalin activity at opioid receptors in skin. Enkephalins are endogenous neuropeptides that modulate skin neurog... Rigin: Rigin (Palmitoyl Tetrapeptide-7) is a cosmetic peptide with the sequence Pal-GQPR derived from the immunoglobulin G (IgG) Fc region. It is designed to suppress chronic skin inflammation by reducing in...
Which has a longer half-life, Leuphasyl or Rigin?
Leuphasyl half-life: Hours (skin). Rigin half-life: Hours (skin).
Can you stack Leuphasyl and Rigin?
Leuphasyl and Rigin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.