Side-by-Side Comparison · 2026

Leuphasyl vs Syn-ake

Leuphasyl vs Syn-ake — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Leuphasyl
Cosmetic Peptide

Leuphasyl (Acetyl Pentapeptide-18) is a synthetic cosmetic peptide designed to mimic enkephalin activity at opioid receptors in skin. Enkephalins are endogenous neuropeptides that modulate skin neurogenic inflammation and tension signaling in facial muscles....

Calculate Leuphasyl dose →
Syn-ake
Cosmetic Peptide

Syn-ake is a synthetic tripeptide ingredient developed by DSM Nutritional Products that mimics waglerin-1, a peptide toxin from the Temple Pit Viper (Tropidolaemus wagleri). Waglerin-1 blocks nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction, causing sustain...

Calculate Syn-ake dose →
Key Parameters
Parameter Leuphasyl Syn-ake
Category Cosmetic Peptide Cosmetic Peptide
Research Cosmetic Use Cosmetic Use
Half-Life Hours (skin) Hours (skin)
Typical Dose 0.001-0.01% in formulation 0.01-0.05% in formulation
Frequency Twice daily Twice daily
Route Topical Topical
FDA Status Cosmetic ingredient (not drug) Cosmetic ingredient

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Leuphasyl Calculate Syn-ake
Frequently Asked Questions
What is the difference between Leuphasyl and Syn-ake?
Leuphasyl: Leuphasyl (Acetyl Pentapeptide-18) is a synthetic cosmetic peptide designed to mimic enkephalin activity at opioid receptors in skin. Enkephalins are endogenous neuropeptides that modulate skin neurog... Syn-ake: Syn-ake is a synthetic tripeptide ingredient developed by DSM Nutritional Products that mimics waglerin-1, a peptide toxin from the Temple Pit Viper (Tropidolaemus wagleri). Waglerin-1 blocks nicotini...
Which has a longer half-life, Leuphasyl or Syn-ake?
Leuphasyl half-life: Hours (skin). Syn-ake half-life: Hours (skin).
Can you stack Leuphasyl and Syn-ake?
Leuphasyl and Syn-ake are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.