Side-by-Side Comparison · 2026

Magainin vs Protegrin

Magainin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Magainin
Antimicrobial Peptide

Magainins are cationic, alpha-helical antimicrobial peptides (AMPs) isolated from the skin of the African clawed frog Xenopus laevis by Michael Zasloff in 1987. They are among the founding members of the frog skin AMP family and established the concept of innate immune peptide de...

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Magainin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical (topical) Phase III (failed)
Half-Life Minutes (plasma); hours (topical) Hours (disulfide stabilized)
Typical Dose Pexiganan cream 0.8% N/A
Frequency Twice daily (topical) N/A
Route Topical (clinical), IV (research) Topical / Rinse
FDA Status Under review (pexiganan) Not approved

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Frequently Asked Questions
What is the difference between Magainin and Protegrin?
Magainin: Magainins are cationic, alpha-helical antimicrobial peptides (AMPs) isolated from the skin of the African clawed frog Xenopus laevis by Michael Zasloff in 1987. They are among the founding members of ... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Magainin or Protegrin?
Magainin half-life: Minutes (plasma); hours (topical). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Magainin and Protegrin?
Magainin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.