Side-by-Side Comparison · 2026

Magainin vs Tachyplesin

Magainin vs Tachyplesin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Magainin
Antimicrobial Peptide

Magainins are cationic, alpha-helical antimicrobial peptides (AMPs) isolated from the skin of the African clawed frog Xenopus laevis by Michael Zasloff in 1987. They are among the founding members of the frog skin AMP family and established the concept of innate immune peptide de...

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Tachyplesin
Antimicrobial Peptide

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor activity....

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Key Parameters
Parameter Magainin Tachyplesin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical (topical) Preclinical
Half-Life Minutes (plasma); hours (topical) Hours (disulfide stabilized)
Typical Dose Pexiganan cream 0.8% N/A
Frequency Twice daily (topical) N/A
Route Topical (clinical), IV (research) Research only
FDA Status Under review (pexiganan) Not approved

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Frequently Asked Questions
What is the difference between Magainin and Tachyplesin?
Magainin: Magainins are cationic, alpha-helical antimicrobial peptides (AMPs) isolated from the skin of the African clawed frog Xenopus laevis by Michael Zasloff in 1987. They are among the founding members of ... Tachyplesin: Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor...
Which has a longer half-life, Magainin or Tachyplesin?
Magainin half-life: Minutes (plasma); hours (topical). Tachyplesin half-life: Hours (disulfide stabilized).
Can you stack Magainin and Tachyplesin?
Magainin and Tachyplesin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.