Side-by-Side Comparison · 2026

Mastoparan vs Melittin

Mastoparan vs Melittin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Mastoparan
Venom Peptide

Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface receptors, making it a unique pharmacological tool for dissecting G protein-coupled ...

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Melittin
Venom Peptide

Melittin is the primary cytolytic component of bee venom (Apis mellifera), comprising ~50% of dry venom weight. It is a 26-amino acid amphipathic, cationic peptide that forms an alpha-helix in membrane environments and disrupts lipid bilayers via a detergent-like mechanism....

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Key Parameters
Parameter Mastoparan Melittin
Category Venom Peptide Venom Peptide
Research Preclinical/Research Tool Preclinical
Half-Life < 15 min (plasma) < 30 min (plasma)
Typical Dose Research only Research only
Frequency N/A N/A
Route IV, local (research) IV, topical (research)
FDA Status No approval No approval

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Frequently Asked Questions
What is the difference between Mastoparan and Melittin?
Mastoparan: Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface rece... Melittin: Melittin is the primary cytolytic component of bee venom (Apis mellifera), comprising ~50% of dry venom weight. It is a 26-amino acid amphipathic, cationic peptide that forms an alpha-helix in membran...
Which has a longer half-life, Mastoparan or Melittin?
Mastoparan half-life: < 15 min (plasma). Melittin half-life: < 30 min (plasma).
Can you stack Mastoparan and Melittin?
Mastoparan and Melittin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.