Side-by-Side Comparison · 2026

Mastoparan vs ShK

Mastoparan vs ShK — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Mastoparan
Venom Peptide

Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface receptors, making it a unique pharmacological tool for dissecting G protein-coupled ...

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ShK
Venom Peptide

ShK is a 35-residue peptide toxin from the sea anemone Stichodactyla helianthus. 3 potassium channel (Kd ~11 pM), which is the dominant channel controlling membrane potential in effector memory T cells (TEM cells)....

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Key Parameters
Parameter Mastoparan ShK
Category Venom Peptide Venom Peptide
Research Preclinical/Research Tool Phase 2
Half-Life < 15 min (plasma) Hours (disulfide stabilized)
Typical Dose Research only N/A
Frequency N/A N/A
Route IV, local (research) SC injection (research)
FDA Status No approval Investigational (dalazatide)

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Frequently Asked Questions
What is the difference between Mastoparan and ShK?
Mastoparan: Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface rece... ShK: ShK is a 35-residue peptide toxin from the sea anemone Stichodactyla helianthus. 3 potassium channel (Kd ~11 pM), which is the dominant channel controlling membrane potential in effector memory T cell...
Which has a longer half-life, Mastoparan or ShK?
Mastoparan half-life: < 15 min (plasma). ShK half-life: Hours (disulfide stabilized).
Can you stack Mastoparan and ShK?
Mastoparan and ShK are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.