Side-by-Side Comparison · 2026

Matrixyl vs Palmitoyl Pentapeptide-4

Matrixyl vs Palmitoyl Pentapeptide-4 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Matrixyl
Skin & Cosmetic

Matrixyl is the trade name for Palmitoyl Pentapeptide-4 (Pal-KTTKS), developed by Sederma (now Croda). It is derived from a procollagen type I C-terminal propeptide fragment and uses palmitoylation to cross the skin lipid barrier and reach dermal fibroblasts....

Calculate Matrixyl dose →
Palmitoyl Pentapeptide-4
Skin & Cosmetic

Palmitoyl Pentapeptide-4 (Pal-KTTKS, also marketed as Matrixyl) is a cosmetic peptide derived from a fragment of procollagen type I. The palmitoyl fatty acid attachment allows it to penetrate the skin lipid barrier and reach dermal fibroblasts....

Calculate Palmitoyl Pentapeptide-4 dose →
Key Parameters
Parameter Matrixyl Palmitoyl Pentapeptide-4
Category Skin & Cosmetic Skin & Cosmetic
Research Widely Used (Cosmetic) Widely Used (Cosmetic)
Half-Life - -
Typical Dose 3–5% in formulation 3–5% in formulation
Frequency Twice daily Once or twice daily
Route Topical Topical
FDA Status Not Approved (Cosmetic) Not Approved (Cosmetic Ingredient)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Matrixyl Calculate Palmitoyl Pentapeptide-4
Frequently Asked Questions
What is the difference between Matrixyl and Palmitoyl Pentapeptide-4?
Matrixyl: Matrixyl is the trade name for Palmitoyl Pentapeptide-4 (Pal-KTTKS), developed by Sederma (now Croda). It is derived from a procollagen type I C-terminal propeptide fragment and uses palmitoylation to... Palmitoyl Pentapeptide-4: Palmitoyl Pentapeptide-4 (Pal-KTTKS, also marketed as Matrixyl) is a cosmetic peptide derived from a fragment of procollagen type I. The palmitoyl fatty acid attachment allows it to penetrate the skin...
Which has a longer half-life, Matrixyl or Palmitoyl Pentapeptide-4?
Matrixyl half-life: unknown. Palmitoyl Pentapeptide-4 half-life: unknown.
Can you stack Matrixyl and Palmitoyl Pentapeptide-4?
Matrixyl and Palmitoyl Pentapeptide-4 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.