Side-by-Side Comparison · 2026

MGF vs MK-677

MGF vs MK-677 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

MGF
Growth Hormone & IGF

Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in response to muscle damage or exercise-induced mechanical loading....

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MK-677
Growth Hormone & IGF

MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advanced through Phase II trials for growth hormone deficiency, muscle wasting, and fra...

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Key Parameters
Parameter MGF MK-677
Category Growth Hormone & IGF Growth Hormone & IGF
Research Research Use Phase II (Discontinued)
Half-Life ~5–7 minutes (non-PEGylated) ~24 hours
Typical Dose 100–200 µg 10–25 mg
Frequency Post-workout, 3–5x/week Once daily
Route Subcutaneous / Intramuscular (local) Oral
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between MGF and MK-677?
MGF: Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in resp... MK-677: MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advance...
Which has a longer half-life, MGF or MK-677?
MGF half-life: ~5–7 minutes (non-PEGylated). MK-677 half-life: ~24 hours.
Can you stack MGF and MK-677?
MGF and MK-677 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.