Side-by-Side Comparison · 2026

N-Acetyl Selank Amidate vs PE-22-28

N-Acetyl Selank Amidate vs PE-22-28 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

N-Acetyl Selank Amidate
Cognitive & Neurological

N-Acetyl Selank Amidate is a doubly-modified form of Selank (a synthetic heptapeptide based on tuftsin) with N-acetylation at the N-terminus and amidation at the C-terminus. These modifications extend enzymatic stability and CNS bioavailability, making it the highest-potency form...

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PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Key Parameters
Parameter N-Acetyl Selank Amidate PE-22-28
Category Cognitive & Neurological Cognitive & Neurological
Research Research Use Preclinical
Half-Life ~6–8 hours (estimated; extended vs. standard Selank) -
Typical Dose 100–300 µg 100–200 µg
Frequency Once or twice daily Daily
Route Intranasal Subcutaneous / Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between N-Acetyl Selank Amidate and PE-22-28?
N-Acetyl Selank Amidate: N-Acetyl Selank Amidate is a doubly-modified form of Selank (a synthetic heptapeptide based on tuftsin) with N-acetylation at the N-terminus and amidation at the C-terminus. These modifications extend... PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re...
Which has a longer half-life, N-Acetyl Selank Amidate or PE-22-28?
N-Acetyl Selank Amidate half-life: ~6–8 hours (estimated; extended vs. standard Selank). PE-22-28 half-life: unknown.
Can you stack N-Acetyl Selank Amidate and PE-22-28?
N-Acetyl Selank Amidate and PE-22-28 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.