Side-by-Side Comparison · 2026

N-Acetyl Selank Amidate vs Semax Amidate

N-Acetyl Selank Amidate vs Semax Amidate — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

N-Acetyl Selank Amidate
Cognitive & Neurological

N-Acetyl Selank Amidate is a doubly-modified form of Selank (a synthetic heptapeptide based on tuftsin) with N-acetylation at the N-terminus and amidation at the C-terminus. These modifications extend enzymatic stability and CNS bioavailability, making it the highest-potency form...

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Semax Amidate
Cognitive & Neurological

Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidase degradation in nasal tissue, extending half-life and improving CNS bioavailabi...

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Key Parameters
Parameter N-Acetyl Selank Amidate Semax Amidate
Category Cognitive & Neurological Cognitive & Neurological
Research Research Use Research Use
Half-Life ~6–8 hours (estimated; extended vs. standard Selank) ~6 hours (estimated)
Typical Dose 100–300 µg 100–400 µg
Frequency Once or twice daily Once or twice daily
Route Intranasal Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between N-Acetyl Selank Amidate and Semax Amidate?
N-Acetyl Selank Amidate: N-Acetyl Selank Amidate is a doubly-modified form of Selank (a synthetic heptapeptide based on tuftsin) with N-acetylation at the N-terminus and amidation at the C-terminus. These modifications extend... Semax Amidate: Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidas...
Which has a longer half-life, N-Acetyl Selank Amidate or Semax Amidate?
N-Acetyl Selank Amidate half-life: ~6–8 hours (estimated; extended vs. standard Selank). Semax Amidate half-life: ~6 hours (estimated).
Can you stack N-Acetyl Selank Amidate and Semax Amidate?
N-Acetyl Selank Amidate and Semax Amidate are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.