Side-by-Side Comparison · 2026

N-Acetyl Semax vs PE-22-28

N-Acetyl Semax vs PE-22-28 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

N-Acetyl Semax
Cognitive & Neurological

N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects against aminopeptidase degradation in nasal tissue, extending effective half-life a...

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PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Key Parameters
Parameter N-Acetyl Semax PE-22-28
Category Cognitive & Neurological Cognitive & Neurological
Research Research Use Preclinical
Half-Life ~4–6 hours (extended vs. standard Semax) -
Typical Dose 100–400 µg 100–200 µg
Frequency Once or twice daily Daily
Route Intranasal Subcutaneous / Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between N-Acetyl Semax and PE-22-28?
N-Acetyl Semax: N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects aga... PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re...
Which has a longer half-life, N-Acetyl Semax or PE-22-28?
N-Acetyl Semax half-life: ~4–6 hours (extended vs. standard Semax). PE-22-28 half-life: unknown.
Can you stack N-Acetyl Semax and PE-22-28?
N-Acetyl Semax and PE-22-28 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.