Side-by-Side Comparison · 2026

NAP (Davunetide) vs PACAP-38

NAP (Davunetide) vs PACAP-38 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

NAP (Davunetide)
Neuropeptides & Cognition

NAP (NAPVSIPQ) is an eight-amino-acid neuroprotective peptide derived from Activity-Dependent Neuroprotective Protein (ADNP) - a zinc-finger protein essential for brain formation that is one of the most abundant transcription factors in the brain. First identified by Illana Gozes...

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PACAP-38
Neuropeptides & Cognition

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) is a 38-amino-acid member of the VIP/secretin/glucagon superfamily, first isolated from ovine hypothalamus in 1989 by Miyata and colleagues based on its ability to stimulate adenylate cyclase in pituitary cells. PACAP-...

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Key Parameters
Parameter NAP (Davunetide) PACAP-38
Category Neuropeptides & Cognition Neuropeptides & Cognition
Research Phase II Completed (PSP, Schizophrenia) Extensively Studied (Preclinical)
Half-Life 1-3 h (estimated) 2-5 min (plasma); longer in CNS
Typical Dose 30-300 mcg intranasal 300-600 mcg intranasal; 100-300 mcg SC
Frequency Twice daily As needed or daily for neuroprotection protocols
Route Intranasal (preferred for CNS delivery) Intranasal, Subcutaneous, IV
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between NAP (Davunetide) and PACAP-38?
NAP (Davunetide): NAP (NAPVSIPQ) is an eight-amino-acid neuroprotective peptide derived from Activity-Dependent Neuroprotective Protein (ADNP) - a zinc-finger protein essential for brain formation that is one of the mo... PACAP-38: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) is a 38-amino-acid member of the VIP/secretin/glucagon superfamily, first isolated from ovine hypothalamus in 1989 by Miyata and colleague...
Which has a longer half-life, NAP (Davunetide) or PACAP-38?
NAP (Davunetide) half-life: 1-3 h (estimated). PACAP-38 half-life: 2-5 min (plasma); longer in CNS.
Can you stack NAP (Davunetide) and PACAP-38?
NAP (Davunetide) and PACAP-38 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.