Side-by-Side Comparison · 2026

Neuromedin S vs Neuromedin U

Neuromedin S vs Neuromedin U — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Neuromedin S
Neuropeptide

Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. However, NMS has a markedly different expression pattern: while NMU is broadly exp...

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Neuromedin U
Neuropeptide

Neuromedin U (NMU) is a neuropeptide first isolated from porcine spinal cord and named for its ability to contract the uterus. Two bioactive forms exist in humans: the shorter NMU-23 and the predominant NMU-25, both C-terminally amidated....

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Key Parameters
Parameter Neuromedin S Neuromedin U
Category Neuropeptide Neuropeptide
Research Research Research
Half-Life Short (minutes, estimated) Short (minutes)
Typical Dose 1-10 nmol (central, animal) 1-10 nmol/kg (animal)
Frequency Variable Variable
Route Intracerebroventricular, Subcutaneous Subcutaneous, Intracerebroventricular
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Neuromedin S and Neuromedin U?
Neuromedin S: Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. Ho... Neuromedin U: Neuromedin U (NMU) is a neuropeptide first isolated from porcine spinal cord and named for its ability to contract the uterus. Two bioactive forms exist in humans: the shorter NMU-23 and the predomina...
Which has a longer half-life, Neuromedin S or Neuromedin U?
Neuromedin S half-life: Short (minutes, estimated). Neuromedin U half-life: Short (minutes).
Can you stack Neuromedin S and Neuromedin U?
Neuromedin S and Neuromedin U are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.