Side-by-Side Comparison · 2026

Neuromedin S vs Relaxin-3

Neuromedin S vs Relaxin-3 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Neuromedin S
Neuropeptide

Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. However, NMS has a markedly different expression pattern: while NMU is broadly exp...

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Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

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Key Parameters
Parameter Neuromedin S Relaxin-3
Category Neuropeptide Neuropeptide
Research Research Preclinical Research
Half-Life Short (minutes, estimated) ~30-60 minutes (estimated)
Typical Dose 1-10 nmol (central, animal) 100-500 pmol ICV; 1-3 nmol/kg SC
Frequency Variable Single or twice daily (preclinical)
Route Intracerebroventricular, Subcutaneous ICV, SC (preclinical)
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Neuromedin S and Relaxin-3?
Neuromedin S: Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. Ho... Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre...
Which has a longer half-life, Neuromedin S or Relaxin-3?
Neuromedin S half-life: Short (minutes, estimated). Relaxin-3 half-life: ~30-60 minutes (estimated).
Can you stack Neuromedin S and Relaxin-3?
Neuromedin S and Relaxin-3 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.