Side-by-Side Comparison · 2026

Neuropeptide S vs Relaxin-3

Neuropeptide S vs Relaxin-3 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Neuropeptide S
Neuropeptide

Neuropeptide S (NPS) is a 20-amino acid peptide discovered in 2004 that acts on the NPS receptor (NPSR1), a Gq/Gs-coupled GPCR with highest expression in amygdala, hypothalamus, and brainstem arousal centers. NPS produces a distinctive combination of simultaneous wakefulness prom...

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Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

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Key Parameters
Parameter Neuropeptide S Relaxin-3
Category Neuropeptide Neuropeptide
Research Preclinical Preclinical Research
Half-Life Short (minutes, CNS) ~30-60 minutes (estimated)
Typical Dose 0.1-10 nmol (ICV, animal) 100-500 pmol ICV; 1-3 nmol/kg SC
Frequency Variable Single or twice daily (preclinical)
Route Intracerebroventricular (animal research) ICV, SC (preclinical)
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Neuropeptide S and Relaxin-3?
Neuropeptide S: Neuropeptide S (NPS) is a 20-amino acid peptide discovered in 2004 that acts on the NPS receptor (NPSR1), a Gq/Gs-coupled GPCR with highest expression in amygdala, hypothalamus, and brainstem arousal ... Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre...
Which has a longer half-life, Neuropeptide S or Relaxin-3?
Neuropeptide S half-life: Short (minutes, CNS). Relaxin-3 half-life: ~30-60 minutes (estimated).
Can you stack Neuropeptide S and Relaxin-3?
Neuropeptide S and Relaxin-3 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.