Side-by-Side Comparison · 2026

Neurotensin vs Relaxin-3

Neurotensin vs Relaxin-3 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Neurotensin
Neuropeptide

Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed throughout the central and peripheral nervous systems, with high concentrations in the hypothalamus, nucleus accumbens, and gastrointestinal tract. Discovered in 1973, neurotensin modulates dopaminergic signaling...

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Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

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Key Parameters
Parameter Neurotensin Relaxin-3
Category Neuropeptide Neuropeptide
Research Research Preclinical Research
Half-Life < 5 min (plasma) ~30-60 minutes (estimated)
Typical Dose 1-10 nmol/kg (animal) 100-500 pmol ICV; 1-3 nmol/kg SC
Frequency Variable Single or twice daily (preclinical)
Route Subcutaneous, Intracerebroventricular ICV, SC (preclinical)
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Neurotensin and Relaxin-3?
Neurotensin: Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed throughout the central and peripheral nervous systems, with high concentrations in the hypothalamus, nucleus accumbens, and gastroin... Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre...
Which has a longer half-life, Neurotensin or Relaxin-3?
Neurotensin half-life: < 5 min (plasma). Relaxin-3 half-life: ~30-60 minutes (estimated).
Can you stack Neurotensin and Relaxin-3?
Neurotensin and Relaxin-3 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.