Side-by-Side Comparison · 2026

Nisin vs Omiganan

Nisin vs Omiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Nisin
Antimicrobial Peptide

Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food preservative in dairy, canned goods, and processed meats....

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Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Key Parameters
Parameter Nisin Omiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research GRAS Food Use / Preclinical (medical) Phase 3 (Completed)
Half-Life Minutes-hours (pH and protease dependent) Hours (topical)
Typical Dose N/A (food use to ~500 ppm) 1-3% gel
Frequency N/A Twice daily
Route Topical / Oral (food use) Topical gel/cream
FDA Status GRAS (food) / Investigational (medical) Not approved

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Frequently Asked Questions
What is the difference between Nisin and Omiganan?
Nisin: Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food p... Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve...
Which has a longer half-life, Nisin or Omiganan?
Nisin half-life: Minutes-hours (pH and protease dependent). Omiganan half-life: Hours (topical).
Can you stack Nisin and Omiganan?
Nisin and Omiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.