Side-by-Side Comparison · 2026

Nisin vs PGLa

Nisin vs PGLa — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Nisin
Antimicrobial Peptide

Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food preservative in dairy, canned goods, and processed meats....

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PGLa
Antimicrobial Peptide

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobial activity, but when combined at equimolar ratios, they exhibit synergistic kill...

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Key Parameters
Parameter Nisin PGLa
Category Antimicrobial Peptide Antimicrobial Peptide
Research GRAS Food Use / Preclinical (medical) Preclinical
Half-Life Minutes-hours (pH and protease dependent) Minutes (proteolytic)
Typical Dose N/A (food use to ~500 ppm) N/A
Frequency N/A N/A
Route Topical / Oral (food use) Research only
FDA Status GRAS (food) / Investigational (medical) Not approved

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Frequently Asked Questions
What is the difference between Nisin and PGLa?
Nisin: Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food p... PGLa: PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobia...
Which has a longer half-life, Nisin or PGLa?
Nisin half-life: Minutes-hours (pH and protease dependent). PGLa half-life: Minutes (proteolytic).
Can you stack Nisin and PGLa?
Nisin and PGLa are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.