Side-by-Side Comparison · 2026

Nisin vs Plectasin

Nisin vs Plectasin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Nisin
Antimicrobial Peptide

Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food preservative in dairy, canned goods, and processed meats....

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Plectasin
Antimicrobial Peptide

Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....

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Key Parameters
Parameter Nisin Plectasin
Category Antimicrobial Peptide Antimicrobial Peptide
Research GRAS Food Use / Preclinical (medical) Preclinical
Half-Life Minutes-hours (pH and protease dependent) Hours (disulfide stabilized)
Typical Dose N/A (food use to ~500 ppm) N/A
Frequency N/A N/A
Route Topical / Oral (food use) Research only
FDA Status GRAS (food) / Investigational (medical) Not approved

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Frequently Asked Questions
What is the difference between Nisin and Plectasin?
Nisin: Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food p... Plectasin: Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....
Which has a longer half-life, Nisin or Plectasin?
Nisin half-life: Minutes-hours (pH and protease dependent). Plectasin half-life: Hours (disulfide stabilized).
Can you stack Nisin and Plectasin?
Nisin and Plectasin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.