Side-by-Side Comparison · 2026

Omiganan vs Pexiganan

Omiganan vs Pexiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Key Parameters
Parameter Omiganan Pexiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Completed) Phase 3 (Failed 1999)
Half-Life Hours (topical) Hours (topical)
Typical Dose 1-3% gel 0.8% cream topically
Frequency Twice daily Twice daily
Route Topical gel/cream Topical cream
FDA Status Not approved Not approved (failed Phase 3)

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Frequently Asked Questions
What is the difference between Omiganan and Pexiganan?
Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve... Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later...
Which has a longer half-life, Omiganan or Pexiganan?
Omiganan half-life: Hours (topical). Pexiganan half-life: Hours (topical).
Can you stack Omiganan and Pexiganan?
Omiganan and Pexiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.