Side-by-Side Comparison · 2026

Omiganan vs PGLa

Omiganan vs PGLa — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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PGLa
Antimicrobial Peptide

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobial activity, but when combined at equimolar ratios, they exhibit synergistic kill...

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Key Parameters
Parameter Omiganan PGLa
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Completed) Preclinical
Half-Life Hours (topical) Minutes (proteolytic)
Typical Dose 1-3% gel N/A
Frequency Twice daily N/A
Route Topical gel/cream Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Omiganan and PGLa?
Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve... PGLa: PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobia...
Which has a longer half-life, Omiganan or PGLa?
Omiganan half-life: Hours (topical). PGLa half-life: Minutes (proteolytic).
Can you stack Omiganan and PGLa?
Omiganan and PGLa are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.