Side-by-Side Comparison · 2026

Omiganan vs Phylloseptin

Omiganan vs Phylloseptin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Phylloseptin
Antimicrobial Peptide

Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins from the same genus, phylloseptins are shorter (19 residues) and show a distinct...

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Key Parameters
Parameter Omiganan Phylloseptin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Completed) Preclinical
Half-Life Hours (topical) Minutes (proteolytic)
Typical Dose 1-3% gel N/A
Frequency Twice daily N/A
Route Topical gel/cream Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Omiganan and Phylloseptin?
Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve... Phylloseptin: Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins ...
Which has a longer half-life, Omiganan or Phylloseptin?
Omiganan half-life: Hours (topical). Phylloseptin half-life: Minutes (proteolytic).
Can you stack Omiganan and Phylloseptin?
Omiganan and Phylloseptin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.