Side-by-Side Comparison · 2026

Omiganan vs Ponericin

Omiganan vs Ponericin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Ponericin
Antimicrobial Peptide

Ponericins are a family of antimicrobial peptides isolated from the venom of the ant Pachycondyla goeldii. They adopt alpha-helical conformations in membrane environments and display broad-spectrum antibacterial and insecticidal activity....

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Key Parameters
Parameter Omiganan Ponericin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Completed) Preclinical
Half-Life Hours (topical) Short
Typical Dose 1-3% gel N/A (research only)
Frequency Twice daily N/A
Route Topical gel/cream Topical / Systemic (research)
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Omiganan and Ponericin?
Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve... Ponericin: Ponericins are a family of antimicrobial peptides isolated from the venom of the ant Pachycondyla goeldii. They adopt alpha-helical conformations in membrane environments and display broad-spectrum an...
Which has a longer half-life, Omiganan or Ponericin?
Omiganan half-life: Hours (topical). Ponericin half-life: Short.
Can you stack Omiganan and Ponericin?
Omiganan and Ponericin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.