Side-by-Side Comparison · 2026

Omiganan vs Ramoplanin

Omiganan vs Ramoplanin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Ramoplanin
Antimicrobial Peptide

Ramoplanin is a glycodepsipeptide antibiotic produced by Actinoplanes sp. ATCC 33076 with potent activity against gram-positive bacteria....

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Key Parameters
Parameter Omiganan Ramoplanin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Completed) Phase 3 (Discontinued)
Half-Life Hours (topical) Short (gut lumen)
Typical Dose 1-3% gel 200 mg twice daily
Frequency Twice daily Twice daily
Route Topical gel/cream Oral (non-absorbed)
FDA Status Not approved Not approved (Phase 3 discontinued)

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Frequently Asked Questions
What is the difference between Omiganan and Ramoplanin?
Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve... Ramoplanin: Ramoplanin is a glycodepsipeptide antibiotic produced by Actinoplanes sp. ATCC 33076 with potent activity against gram-positive bacteria....
Which has a longer half-life, Omiganan or Ramoplanin?
Omiganan half-life: Hours (topical). Ramoplanin half-life: Short (gut lumen).
Can you stack Omiganan and Ramoplanin?
Omiganan and Ramoplanin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.