Side-by-Side Comparison · 2026

OTR-AC vs TB-500

OTR-AC vs TB-500 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

OTR-AC
Healing & Recovery

OTR-AC is the common name for oral high-dose BPC-157 acetate. The peptide sequence (GEPPPGKPADDAGLV) is identical to injectable BPC-157 but is dosed at 2–5 mg orally rather than 250–500 µg subcutaneously to compensate for GI degradation and first-pass metabolism. The oral route p...

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TB-500
Healing & Recovery

TB-500 is a synthetic fragment of Thymosin Beta-4, concentrated naturally in platelets and wound fluid. It promotes cell migration, angiogenesis, and systemic tissue repair via actin polymerization. Half-life of approximately 5 days enables twice-weekly dosing. WADA prohibited un...

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Key Parameters
Parameter OTR-AC TB-500
Category Healing & Recovery Healing & Recovery
Research Preclinical Extensively Studied
Half-Life 4–6 hours (estimated, oral) ~5 days
Typical Dose 2–5 mg 2.5–5 mg
Frequency Once daily 2–3× per week
Route Oral Subcutaneous
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between OTR-AC and TB-500?
OTR-AC: OTR-AC is the common name for oral high-dose BPC-157 acetate. The peptide sequence (GEPPPGKPADDAGLV) is identical to injectable BPC-157 but is dosed at 2–5 mg orally rather than 250–500 µg subcutaneou... TB-500: TB-500 is a synthetic fragment of Thymosin Beta-4, concentrated naturally in platelets and wound fluid. It promotes cell migration, angiogenesis, and systemic tissue repair via actin polymerization. H...
Which has a longer half-life, OTR-AC or TB-500?
OTR-AC half-life: 4–6 hours (estimated, oral). TB-500 half-life: ~5 days.
Can you stack OTR-AC and TB-500?
OTR-AC and TB-500 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.