Side-by-Side Comparison · 2026

PE-22-28 vs Semax Amidate

PE-22-28 vs Semax Amidate — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Semax Amidate
Cognitive & Neurological

Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidase degradation in nasal tissue, extending half-life and improving CNS bioavailabi...

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Key Parameters
Parameter PE-22-28 Semax Amidate
Category Cognitive & Neurological Cognitive & Neurological
Research Preclinical Research Use
Half-Life - ~6 hours (estimated)
Typical Dose 100–200 µg 100–400 µg
Frequency Daily Once or twice daily
Route Subcutaneous / Intranasal Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between PE-22-28 and Semax Amidate?
PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re... Semax Amidate: Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidas...
Which has a longer half-life, PE-22-28 or Semax Amidate?
PE-22-28 half-life: unknown. Semax Amidate half-life: ~6 hours (estimated).
Can you stack PE-22-28 and Semax Amidate?
PE-22-28 and Semax Amidate are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.