Side-by-Side Comparison · 2026

PE-22-28 vs Synapsin

PE-22-28 vs Synapsin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Synapsin
Cognitive & Neurological

Synapsin is a proprietary intranasal peptide blend combining GHK-Cu (copper tripeptide for neuroregenerative and anti-inflammatory effects) and Dihexa (a potent HGF/c-Met agonist for synaptogenesis and memory). The combination targets synaptic density and cognitive performance fr...

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Key Parameters
Parameter PE-22-28 Synapsin
Category Cognitive & Neurological Cognitive & Neurological
Research Preclinical Vendor Blend
Half-Life - -
Typical Dose 100–200 µg -
Frequency Daily -
Route Subcutaneous / Intranasal Intranasal
FDA Status Not Approved Not Approved

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Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

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Frequently Asked Questions
What is the difference between PE-22-28 and Synapsin?
PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re... Synapsin: Synapsin is a proprietary intranasal peptide blend combining GHK-Cu (copper tripeptide for neuroregenerative and anti-inflammatory effects) and Dihexa (a potent HGF/c-Met agonist for synaptogenesis an...
Which has a longer half-life, PE-22-28 or Synapsin?
PE-22-28 half-life: unknown. Synapsin half-life: unknown.
Can you stack PE-22-28 and Synapsin?
PE-22-28 and Synapsin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.