Side-by-Side Comparison · 2026

Pexiganan vs Phylloseptin

Pexiganan vs Phylloseptin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Phylloseptin
Antimicrobial Peptide

Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins from the same genus, phylloseptins are shorter (19 residues) and show a distinct...

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Key Parameters
Parameter Pexiganan Phylloseptin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Failed 1999) Preclinical
Half-Life Hours (topical) Minutes (proteolytic)
Typical Dose 0.8% cream topically N/A
Frequency Twice daily N/A
Route Topical cream Research only
FDA Status Not approved (failed Phase 3) Not approved

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Frequently Asked Questions
What is the difference between Pexiganan and Phylloseptin?
Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later... Phylloseptin: Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins ...
Which has a longer half-life, Pexiganan or Phylloseptin?
Pexiganan half-life: Hours (topical). Phylloseptin half-life: Minutes (proteolytic).
Can you stack Pexiganan and Phylloseptin?
Pexiganan and Phylloseptin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.