Side-by-Side Comparison · 2026

Pexiganan vs Plectasin

Pexiganan vs Plectasin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Plectasin
Antimicrobial Peptide

Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....

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Key Parameters
Parameter Pexiganan Plectasin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 (Failed 1999) Preclinical
Half-Life Hours (topical) Hours (disulfide stabilized)
Typical Dose 0.8% cream topically N/A
Frequency Twice daily N/A
Route Topical cream Research only
FDA Status Not approved (failed Phase 3) Not approved

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Frequently Asked Questions
What is the difference between Pexiganan and Plectasin?
Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later... Plectasin: Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....
Which has a longer half-life, Pexiganan or Plectasin?
Pexiganan half-life: Hours (topical). Plectasin half-life: Hours (disulfide stabilized).
Can you stack Pexiganan and Plectasin?
Pexiganan and Plectasin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.