Side-by-Side Comparison · 2026

PGLa vs Polyphemusin

PGLa vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

PGLa
Antimicrobial Peptide

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobial activity, but when combined at equimolar ratios, they exhibit synergistic kill...

Calculate PGLa dose →
Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

Calculate Polyphemusin dose →
Key Parameters
Parameter PGLa Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate PGLa Calculate Polyphemusin
Frequently Asked Questions
What is the difference between PGLa and Polyphemusin?
PGLa: PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobia... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, PGLa or Polyphemusin?
PGLa half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack PGLa and Polyphemusin?
PGLa and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.