Side-by-Side Comparison · 2026

Phylloseptin vs Polyphemusin

Phylloseptin vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Phylloseptin
Antimicrobial Peptide

Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins from the same genus, phylloseptins are shorter (19 residues) and show a distinct...

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Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Key Parameters
Parameter Phylloseptin Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Phylloseptin and Polyphemusin?
Phylloseptin: Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins ... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Phylloseptin or Polyphemusin?
Phylloseptin half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Phylloseptin and Polyphemusin?
Phylloseptin and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.