Side-by-Side Comparison · 2026

Plectasin vs Tyrocidine

Plectasin vs Tyrocidine — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Plectasin
Antimicrobial Peptide

Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....

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Tyrocidine
Antimicrobial Peptide

Tyrocidine A is a cyclic decapeptide component of tyrothricin, one of the first antibiotic mixtures produced commercially. Isolated from Bacillus brevis soil bacteria, tyrocidines are non-ribosomally synthesized peptides that disrupt bacterial membranes through a carpet mechanism...

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Key Parameters
Parameter Plectasin Tyrocidine
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (disulfide stabilized) Short
Typical Dose N/A N/A (component of tyrothricin)
Frequency N/A N/A
Route Research only Topical (historical)
FDA Status Not approved Not approved (part of historical tyrothricin)

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Frequently Asked Questions
What is the difference between Plectasin and Tyrocidine?
Plectasin: Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism.... Tyrocidine: Tyrocidine A is a cyclic decapeptide component of tyrothricin, one of the first antibiotic mixtures produced commercially. Isolated from Bacillus brevis soil bacteria, tyrocidines are non-ribosomally ...
Which has a longer half-life, Plectasin or Tyrocidine?
Plectasin half-life: Hours (disulfide stabilized). Tyrocidine half-life: Short.
Can you stack Plectasin and Tyrocidine?
Plectasin and Tyrocidine are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.