Side-by-Side Comparison · 2026

Polymyxin B vs Protegrin-1

Polymyxin B vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Polymyxin B
Antimicrobial Peptide

Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a last-resort treatment for carbapenem-resistant Gram-negative infections (Acinetob...

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Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

Calculate Protegrin-1 dose →
Key Parameters
Parameter Polymyxin B Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research FDA Approved Phase 3 / Clinical
Half-Life 6-8 hours Short
Typical Dose 15,000-25,000 units/kg/day IV 0.1-1 mg/mL (topical)
Frequency Every 12 hours IV BID-TID
Route IV / IM / Topical / Intrathecal Topical / Oral rinse (research)
FDA Status Approved (systemic Gram-negative infections) Phase 3 clinical evaluation (iseganan)

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Frequently Asked Questions
What is the difference between Polymyxin B and Protegrin-1?
Polymyxin B: Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a l... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Polymyxin B or Protegrin-1?
Polymyxin B half-life: 6-8 hours. Protegrin-1 half-life: Short.
Can you stack Polymyxin B and Protegrin-1?
Polymyxin B and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.