Side-by-Side Comparison · 2026

Polyphemusin vs Protegrin

Polyphemusin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

Calculate Polyphemusin dose →
Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

Calculate Protegrin dose →
Key Parameters
Parameter Polyphemusin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Hours (disulfide stabilized) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Topical / Rinse
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Polyphemusin Calculate Protegrin
Frequently Asked Questions
What is the difference between Polyphemusin and Protegrin?
Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Polyphemusin or Protegrin?
Polyphemusin half-life: Hours (disulfide stabilized). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Polyphemusin and Protegrin?
Polyphemusin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.