Side-by-Side Comparison · 2026

Polyphemusin vs Tachyplesin

Polyphemusin vs Tachyplesin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Tachyplesin
Antimicrobial Peptide

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor activity....

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Key Parameters
Parameter Polyphemusin Tachyplesin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (disulfide stabilized) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Polyphemusin and Tachyplesin?
Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis... Tachyplesin: Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor...
Which has a longer half-life, Polyphemusin or Tachyplesin?
Polyphemusin half-life: Hours (disulfide stabilized). Tachyplesin half-life: Hours (disulfide stabilized).
Can you stack Polyphemusin and Tachyplesin?
Polyphemusin and Tachyplesin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.