Side-by-Side Comparison · 2026

Polyphemusin vs Tigerinin

Polyphemusin vs Tigerinin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Tigerinin
Antimicrobial Peptide

Tigerinin peptides are isolated from the skin of the Indian skipper frog Hoplobatrachus tigerinus. They are among the shortest naturally occurring AMPs....

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Key Parameters
Parameter Polyphemusin Tigerinin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (disulfide stabilized) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Polyphemusin and Tigerinin?
Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis... Tigerinin: Tigerinin peptides are isolated from the skin of the Indian skipper frog Hoplobatrachus tigerinus. They are among the shortest naturally occurring AMPs....
Which has a longer half-life, Polyphemusin or Tigerinin?
Polyphemusin half-life: Hours (disulfide stabilized). Tigerinin half-life: Minutes (proteolytic).
Can you stack Polyphemusin and Tigerinin?
Polyphemusin and Tigerinin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.