Side-by-Side Comparison · 2026

PR-39 vs Tachyplesin

PR-39 vs Tachyplesin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

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Tachyplesin
Antimicrobial Peptide

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor activity....

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Key Parameters
Parameter PR-39 Tachyplesin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between PR-39 and Tachyplesin?
PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D... Tachyplesin: Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor...
Which has a longer half-life, PR-39 or Tachyplesin?
PR-39 half-life: Minutes (proteolytic). Tachyplesin half-life: Hours (disulfide stabilized).
Can you stack PR-39 and Tachyplesin?
PR-39 and Tachyplesin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.