Side-by-Side Comparison · 2026

Protegrin-1 vs Teixobactin

Protegrin-1 vs Teixobactin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

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Teixobactin
Antimicrobial Peptide

Teixobactin was reported in Nature in 2015 as the first new antibiotic class discovered in 30 years, isolated from uncultured soil bacteria Eleftheria terrae using the iChip (isolation chip) technology that allows cultivation of previously unculturable organisms. Teixobactin bind...

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Key Parameters
Parameter Protegrin-1 Teixobactin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase 3 / Clinical Preclinical
Half-Life Short Hours (in vivo)
Typical Dose 0.1-1 mg/mL (topical) N/A
Frequency BID-TID N/A
Route Topical / Oral rinse (research) Research only (IV in animal studies)
FDA Status Phase 3 clinical evaluation (iseganan) Not approved (preclinical)

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Frequently Asked Questions
What is the difference between Protegrin-1 and Teixobactin?
Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat... Teixobactin: Teixobactin was reported in Nature in 2015 as the first new antibiotic class discovered in 30 years, isolated from uncultured soil bacteria Eleftheria terrae using the iChip (isolation chip) technolog...
Which has a longer half-life, Protegrin-1 or Teixobactin?
Protegrin-1 half-life: Short. Teixobactin half-life: Hours (in vivo).
Can you stack Protegrin-1 and Teixobactin?
Protegrin-1 and Teixobactin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.