Side-by-Side Comparison · 2026

Protegrin vs Tachyplesin

Protegrin vs Tachyplesin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Tachyplesin
Antimicrobial Peptide

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor activity....

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Key Parameters
Parameter Protegrin Tachyplesin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase III (failed) Preclinical
Half-Life Hours (disulfide stabilized) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Topical / Rinse Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Protegrin and Tachyplesin?
Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba... Tachyplesin: Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor...
Which has a longer half-life, Protegrin or Tachyplesin?
Protegrin half-life: Hours (disulfide stabilized). Tachyplesin half-life: Hours (disulfide stabilized).
Can you stack Protegrin and Tachyplesin?
Protegrin and Tachyplesin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.