Side-by-Side Comparison · 2026

Protegrin vs Temporin

Protegrin vs Temporin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Temporin
Antimicrobial Peptide

Temporins are a family of short (10-14 amino acid) cationic antimicrobial peptides isolated from the skin secretions of the European common frog (Rana temporaria). First described by Simmaco et al....

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Key Parameters
Parameter Protegrin Temporin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase III (failed) Preclinical
Half-Life Hours (disulfide stabilized) Minutes (plasma)
Typical Dose N/A Research only
Frequency N/A N/A
Route Topical / Rinse Topical, in vitro (research)
FDA Status Not approved No approval

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Frequently Asked Questions
What is the difference between Protegrin and Temporin?
Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba... Temporin: Temporins are a family of short (10-14 amino acid) cationic antimicrobial peptides isolated from the skin secretions of the European common frog (Rana temporaria). First described by Simmaco et al....
Which has a longer half-life, Protegrin or Temporin?
Protegrin half-life: Hours (disulfide stabilized). Temporin half-life: Minutes (plasma).
Can you stack Protegrin and Temporin?
Protegrin and Temporin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.