Side-by-Side Comparison · 2026

Relaxin-2 vs Urocortin

Relaxin-2 vs Urocortin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Urocortin
Cardiovascular Peptide

Urocortin 1 (UCN1) is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. While sharing structural homology with CRF, UCN1 binds with higher affinity to CRF receptor type 2 (CRFR2), which predominates in the heart, skeletal muscle, and peripheral...

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Key Parameters
Parameter Relaxin-2 Urocortin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Clinical
Half-Life 10-15 min (plasma) 1-3 hours
Typical Dose 30-300 mcg/kg/day (IV) 0.5-10 pmol/kg/min (IV infusion)
Frequency Continuous 48-hour infusion (trials) Acute infusion or short courses
Route Intravenous (infusion) Intravenous, Subcutaneous
FDA Status Not approved (Phase III completed) Not approved

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Frequently Asked Questions
What is the difference between Relaxin-2 and Urocortin?
Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis... Urocortin: Urocortin 1 (UCN1) is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. While sharing structural homology with CRF, UCN1 binds with higher affinity to CRF receptor ...
Which has a longer half-life, Relaxin-2 or Urocortin?
Relaxin-2 half-life: 10-15 min (plasma). Urocortin half-life: 1-3 hours.
Can you stack Relaxin-2 and Urocortin?
Relaxin-2 and Urocortin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.