Side-by-Side Comparison · 2026

Relaxin-3 vs TLQP-21

Relaxin-3 vs TLQP-21 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

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TLQP-21
Neuropeptide

TLQP-21 is a 21-amino acid peptide derived from the C-terminal region of VGF (Nerve Growth Factor-Inducible), a large precursor neuropeptide that is proteolytically cleaved into multiple bioactive fragments. VGF is strongly induced by NGF and BDNF and plays roles in energy homeos...

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Key Parameters
Parameter Relaxin-3 TLQP-21
Category Neuropeptide Neuropeptide
Research Preclinical Research Research
Half-Life ~30-60 minutes (estimated) Unknown
Typical Dose 100-500 pmol ICV; 1-3 nmol/kg SC 1-100 nmol (animal)
Frequency Single or twice daily (preclinical) Variable
Route ICV, SC (preclinical) Intrathecal, Subcutaneous, Intracerebroventricular
FDA Status Research compound Not approved

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Frequently Asked Questions
What is the difference between Relaxin-3 and TLQP-21?
Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre... TLQP-21: TLQP-21 is a 21-amino acid peptide derived from the C-terminal region of VGF (Nerve Growth Factor-Inducible), a large precursor neuropeptide that is proteolytically cleaved into multiple bioactive fra...
Which has a longer half-life, Relaxin-3 or TLQP-21?
Relaxin-3 half-life: ~30-60 minutes (estimated). TLQP-21 half-life: Unknown.
Can you stack Relaxin-3 and TLQP-21?
Relaxin-3 and TLQP-21 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.