Side-by-Side Comparison · 2026

Rigin vs Syn-ake

Rigin vs Syn-ake — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Rigin
Cosmetic Peptide

Rigin (Palmitoyl Tetrapeptide-7) is a cosmetic peptide with the sequence Pal-GQPR derived from the immunoglobulin G (IgG) Fc region. It is designed to suppress chronic skin inflammation by reducing interleukin-6 (IL-6) production in skin fibroblasts and keratinocytes....

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Syn-ake
Cosmetic Peptide

Syn-ake is a synthetic tripeptide ingredient developed by DSM Nutritional Products that mimics waglerin-1, a peptide toxin from the Temple Pit Viper (Tropidolaemus wagleri). Waglerin-1 blocks nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction, causing sustain...

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Key Parameters
Parameter Rigin Syn-ake
Category Cosmetic Peptide Cosmetic Peptide
Research Cosmetic Use Cosmetic Use
Half-Life Hours (skin) Hours (skin)
Typical Dose 0.001-0.01% in formulation 0.01-0.05% in formulation
Frequency Twice daily Twice daily
Route Topical Topical
FDA Status Cosmetic ingredient Cosmetic ingredient

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Frequently Asked Questions
What is the difference between Rigin and Syn-ake?
Rigin: Rigin (Palmitoyl Tetrapeptide-7) is a cosmetic peptide with the sequence Pal-GQPR derived from the immunoglobulin G (IgG) Fc region. It is designed to suppress chronic skin inflammation by reducing in... Syn-ake: Syn-ake is a synthetic tripeptide ingredient developed by DSM Nutritional Products that mimics waglerin-1, a peptide toxin from the Temple Pit Viper (Tropidolaemus wagleri). Waglerin-1 blocks nicotini...
Which has a longer half-life, Rigin or Syn-ake?
Rigin half-life: Hours (skin). Syn-ake half-life: Hours (skin).
Can you stack Rigin and Syn-ake?
Rigin and Syn-ake are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.