Side-by-Side Comparison · 2026

Salusin-Beta vs Urotensin-II

Salusin-Beta vs Urotensin-II — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Salusin-Beta
Vasoactive Peptide

Salusin-beta is a 20-amino acid vasoactive peptide derived from the TOR2A (torsin family 2 member A) gene, which also encodes the related peptide salusin-alpha (28 aa). Discovered in 2003 by Shichiri et al....

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Urotensin-II
Vasoactive Peptide

Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated vascular preparations. Originally characterized in fish urophysis (caudal neurose...

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Key Parameters
Parameter Salusin-Beta Urotensin-II
Category Vasoactive Peptide Vasoactive Peptide
Research Research Active Research
Half-Life Unknown ~30 minutes (plasma)
Typical Dose 1-100 nmol/kg (animal) 0.01-1 nmol/kg/min IV (animal); picomolar concentrations produce vasoconstriction
Frequency Variable Acute infusion
Route Intravenous, Subcutaneous IV infusion (research/clinical studies)
FDA Status Not approved Research compound; UT receptor antagonists in clinical trials

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Frequently Asked Questions
What is the difference between Salusin-Beta and Urotensin-II?
Salusin-Beta: Salusin-beta is a 20-amino acid vasoactive peptide derived from the TOR2A (torsin family 2 member A) gene, which also encodes the related peptide salusin-alpha (28 aa). Discovered in 2003 by Shichiri ... Urotensin-II: Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated v...
Which has a longer half-life, Salusin-Beta or Urotensin-II?
Salusin-Beta half-life: Unknown. Urotensin-II half-life: ~30 minutes (plasma).
Can you stack Salusin-Beta and Urotensin-II?
Salusin-Beta and Urotensin-II are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.