Side-by-Side Comparison · 2026

Sarafotoxin vs Urotensin-II

Sarafotoxin vs Urotensin-II — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Sarafotoxin
Vasoactive Peptide

Sarafotoxins are a family of 21-amino acid peptides isolated from the venom of the Israeli burrowing asp (Atractaspis engaddensis). They are structural and functional homologs of endothelin-1, sharing ~60% sequence identity and acting on the same ETA/ETB receptor subtypes....

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Urotensin-II
Vasoactive Peptide

Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated vascular preparations. Originally characterized in fish urophysis (caudal neurose...

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Key Parameters
Parameter Sarafotoxin Urotensin-II
Category Vasoactive Peptide Vasoactive Peptide
Research Pharmacological Tool Active Research
Half-Life Minutes (plasma) ~30 minutes (plasma)
Typical Dose Research only (nmol/kg) 0.01-1 nmol/kg/min IV (animal); picomolar concentrations produce vasoconstriction
Frequency N/A Acute infusion
Route IV (research only) IV infusion (research/clinical studies)
FDA Status No approval Research compound; UT receptor antagonists in clinical trials

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Frequently Asked Questions
What is the difference between Sarafotoxin and Urotensin-II?
Sarafotoxin: Sarafotoxins are a family of 21-amino acid peptides isolated from the venom of the Israeli burrowing asp (Atractaspis engaddensis). They are structural and functional homologs of endothelin-1, sharing... Urotensin-II: Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated v...
Which has a longer half-life, Sarafotoxin or Urotensin-II?
Sarafotoxin half-life: Minutes (plasma). Urotensin-II half-life: ~30 minutes (plasma).
Can you stack Sarafotoxin and Urotensin-II?
Sarafotoxin and Urotensin-II are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.