Side-by-Side Comparison · 2026

Selank vs Semax

Selank vs Semax — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Selank
Cognitive & Anxiolytic

Selank is a synthetic tuftsin analog approved in Russia for generalized anxiety disorder. It modulates GABA-A receptors and preserves endogenous enkephalins via enkephalinase inhibition, producing anxiolytic and nootropic effects without sedation or dependence. Administered intra...

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Semax
Cognitive & Nootropic

Semax is a synthetic ACTH(4-10) heptapeptide analog approved in Russia for cognitive impairment and ischemic stroke. It upregulates BDNF and TrkB in the hippocampus, enhancing neuroplasticity and focus. Administered primarily intranasally with CNS effects lasting 24+ hours despit...

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Key Parameters
Parameter Selank Semax
Category Cognitive & Anxiolytic Cognitive & Nootropic
Research Extensively Studied Extensively Studied
Half-Life ~2 min (plasma); CNS effects 24h+ ~minutes (plasma); CNS effects 24h+
Typical Dose 250–750 µg intranasal 300–900 µg intranasal
Frequency Once or twice daily Once or twice daily
Route Intranasal (primary) / Subcutaneous Intranasal (primary) / Subcutaneous
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between Selank and Semax?
Selank: Selank is a synthetic tuftsin analog approved in Russia for generalized anxiety disorder. It modulates GABA-A receptors and preserves endogenous enkephalins via enkephalinase inhibition, producing anx... Semax: Semax is a synthetic ACTH(4-10) heptapeptide analog approved in Russia for cognitive impairment and ischemic stroke. It upregulates BDNF and TrkB in the hippocampus, enhancing neuroplasticity and focu...
Which has a longer half-life, Selank or Semax?
Selank half-life: ~2 min (plasma); CNS effects 24h+. Semax half-life: ~minutes (plasma); CNS effects 24h+.
Can you stack Selank and Semax?
Selank and Semax are sometimes used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.