Side-by-Side Comparison · 2026

Sermorelin vs Tesamorelin

Sermorelin vs Tesamorelin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Sermorelin
Growth Hormone

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from 1997 until its voluntary market withdrawal in 2008 for commercial reasons - not...

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Tesamorelin
Growth Hormone

Tesamorelin is an FDA-approved synthetic GHRH analog (Egrifta) modified with trans-3-hexenoic acid to resist DPP-IV enzymatic cleavage, doubling its effective half-life. It restores pulsatile GH secretion and preferentially reduces visceral adipose tissue. Approved in 2010 for HI...

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Key Parameters
Parameter Sermorelin Tesamorelin
Category Growth Hormone Growth Hormone
Research Extensively Studied FDA Approved
Half-Life ~10–20 min ~26–38 min
Typical Dose 200–500 µg 1–2 mg
Frequency Once daily (bedtime) Once daily
Route Subcutaneous Subcutaneous
FDA Status Compounding Only Approved

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Frequently Asked Questions
What is the difference between Sermorelin and Tesamorelin?
Sermorelin: Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from... Tesamorelin: Tesamorelin is an FDA-approved synthetic GHRH analog (Egrifta) modified with trans-3-hexenoic acid to resist DPP-IV enzymatic cleavage, doubling its effective half-life. It restores pulsatile GH secre...
Which has a longer half-life, Sermorelin or Tesamorelin?
Sermorelin half-life: ~10–20 min. Tesamorelin half-life: ~26–38 min.
Can you stack Sermorelin and Tesamorelin?
Sermorelin and Tesamorelin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.