Side-by-Side Comparison · 2026

TB-500 vs Thymosin Beta-4

TB-500 vs Thymosin Beta-4 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

TB-500
Healing & Recovery

TB-500 is a synthetic fragment of Thymosin Beta-4, concentrated naturally in platelets and wound fluid. It promotes cell migration, angiogenesis, and systemic tissue repair via actin polymerization. Half-life of approximately 5 days enables twice-weekly dosing. WADA prohibited un...

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Thymosin Beta-4
Healing & Recovery

Thymosin Beta-4 (TB-4) is the full-length 43-amino acid actin-sequestering peptide from which the commonly used research fragment TB-500 (residues 17-23, LKKTETQ) is derived. TB-4 is the most abundant thymosin-family protein in virtually all mammalian cells, where it maintains th...

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Key Parameters
Parameter TB-500 Thymosin Beta-4
Category Healing & Recovery Healing & Recovery
Research Extensively Studied Extensively Studied
Half-Life ~5 days ~30-60 min (plasma)
Typical Dose 2.5–5 mg 1.5-2.5 mg, 2-3x/week
Frequency 2–3× per week 2-3 times per week
Route Subcutaneous Subcutaneous, IV, Topical, Intranasal
FDA Status Not Approved Phase II

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Frequently Asked Questions
What is the difference between TB-500 and Thymosin Beta-4?
TB-500: TB-500 is a synthetic fragment of Thymosin Beta-4, concentrated naturally in platelets and wound fluid. It promotes cell migration, angiogenesis, and systemic tissue repair via actin polymerization. H... Thymosin Beta-4: Thymosin Beta-4 (TB-4) is the full-length 43-amino acid actin-sequestering peptide from which the commonly used research fragment TB-500 (residues 17-23, LKKTETQ) is derived. TB-4 is the most abundant...
Which has a longer half-life, TB-500 or Thymosin Beta-4?
TB-500 half-life: ~5 days. Thymosin Beta-4 half-life: ~30-60 min (plasma).
Can you stack TB-500 and Thymosin Beta-4?
TB-500 and Thymosin Beta-4 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.