⚖ Head-to-Head · Weekly vs Daily GLP-1

Semaglutide vs Liraglutide

Mechanism, half-life, dosing & research status compared side-by-side.

Semaglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Full Semaglutide profile →
Liraglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity, pediatric obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Liraglutide is a once-daily GLP-1 receptor agonist developed by Novo Nordisk that was the first GLP-1 agent approved for weight management (Saxenda, 2014) and established the proof-of-concept for GLP-1-based obesity phar…
Full Liraglutide profile →
Technical Specs Comparison
MetricSemaglutideLiraglutide
Research Status FDA Approved FDA Approved
Molecular Weight 4113.58 Da 3751.20 Da
Half-Life ~168 hours (7 days) ~13 hours
Peak Time 1-3 days post-injection 8-12 hours post-injection
Typical Dose 0.25-2.4 mg/week (SC); 3-14 mg/day (oral) 0.6-3.0 mg/day
Frequency Once weekly (SC); once daily (oral) Once daily
Route Subcutaneous injection; oral tablet Subcutaneous injection
Amino Acids 31 31
WADA Status Not listed Not listed
FDA Status Approved (T2D, obesity) Approved (T2D, obesity, pediatric obesity)
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Semaglutide plasma levels → Plot →
Frequently Asked Questions
What is the difference between Semaglutide and Liraglutide?
Semaglutide: Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri… Liraglutide: Liraglutide is a once-daily GLP-1 receptor agonist developed by Novo Nordisk that was the first GLP-1 agent approved for weight management (Saxenda, 2014) and established the proof-of-concept for GLP-1-based obesity phar…
Can you stack Semaglutide and Liraglutide?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Semaglutide or Liraglutide?
Semaglutide half-life: ~168 hours (7 days). Liraglutide half-life: ~13 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-15.
● Peer-reviewed sources ● Audit timestamp: 2026-06-15 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Semaglutide profile · Liraglutide profile · All comparisons
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