Protocol
Growth Hormone
Sermorelin GH Protocol [2026]
GHRH analog research for physiological GH restoration, particularly in age-related GH decline models.
Compounds
Sermorelin
Dose: 200 mcg
Freq: Once nightly
Recon: 6mg + 3mL BAC
Conc: 2,000 mcg/mL
Draw: 10 units (U-100)
Calculate Sermorelin dose
Protocol Phases
Phase 1
Months 1 to 2
100 to 200 mcg SubQ nightly at bedtime. Sermorelin has a short half-life and must be dosed close to sleep onset to overlap with the natural nocturnal GH pulse.
Phase 2
Months 3 to 6
200 to 300 mcg nightly. Some protocols add a morning dose at 100 mcg on training days. Effects on IGF-1 typically become measurable by month 2 to 3.
FAQ
How does Sermorelin compare to CJC-1295?
Sermorelin is the native GHRH(1-29) fragment with a very short half-life of 10 to 20 minutes. CJC-1295 is a modified GHRH analog with extended half-life achieved through DAC attachment or amino acid substitutions. Sermorelin requires nightly injection and mimics more physiological pulsatile GH release. CJC-1295 provides longer GH elevation per dose. Sermorelin is considered closer to natural physiology.
When should Sermorelin be injected relative to sleep?
Within 30 minutes of intended sleep. The very short half-life means the effect window must overlap directly with sleep onset for the GH pulse to occur during deep sleep. This makes consistent sleep timing important during a Sermorelin protocol.
How long does it take to see results from Sermorelin?
IGF-1 elevation is typically detectable by weeks 6 to 8. Body composition changes and energy improvements are generally reported at months 3 to 6 in longer protocols. Sermorelin is a slower-onset approach than synthetic GHRPs, reflecting its physiological mechanism.
Research Notes
- Sermorelin must be injected close to sleep onset due to very short half-life.
- Reconstitute with bacteriostatic water. Do not use plain sterile water (no preservative).
- Consistent sleep schedule significantly improves research outcomes. Irregular sleep times reduce the nocturnal GH pulse Sermorelin is designed to amplify.
Related Protocols
For research use only. Not medical advice.